Rio Ferdinand was substituted as a precaution with a tight hamstring during Tuesday night's 1-1 Champions League Group C draw with Valencia at Old Trafford.
Paul Scholes and Patrice Evra both trained away from the main group on Monday in the lead up to that match.
However, all three men are expected to leave Sir Alex with plenty of options for the biggest game of the season so far.
"We're quite confident that everyone will be fit for Monday," the boss told reporters on Friday morning at Carrington. "Rio should be OK. Paul Scholes started full training on Thursday, which is good news, and hopefully we'll have him for Monday. Patrice Evra will be fit.
"Wes Brown and Jonny Evans have had a bit of this flu virus which has been going around, but they both started training on Thursday.
"It's good to have everyone available for such a massive game."
